I have an excel file that exists on an iSeries IFS file system.
I open the Excel workbook from iSeries IFS file system and I delete a column and then use .save to save.
I have .visible = true and I can see the Excel workbook from iSeries IFS file system open, delete the column I wanted deleted.

When the save happens there are no errors message. When .close happens the Excel workbook from iSeries IFS file system closes like expected.

When I copy the Excel workbook from iSeries IFS file system to my desktop PC the column I saw deleted remains in the workbook. However, when I went to open this file in Excel from my desktop I received an error message: "Office File Validation detected a problem while trying to open this file. Opening may be dangerous."

Being there were no error messages when .save happened I was looking forward to the file being saved correctly.

This post may be a long shot for the forum. I am new to VBA projects and there may not be that many folks out there with both iSeries IFS and VBA experience.
Any help would be appreciated.

Below is the code:
The sub I have been testing .save is "DeleteDWRColumn"
In the main excel workbook with these macros there is a path and file for an Excel workbook on IFS file system 

Public index As Integer, workbookname As String, workbookpath As String, sourceworkbook As Workbook, destworkbook As Workbook


Sub DWRUpdate()

    Dim strPathFileName As String
    Dim strDWRcol As String
    Dim strActionFlg As String
    Dim PassFailFlag As String

    Dim iFirstRow As Long
    Dim iLastRow As Long
    Dim searchstring As String
    
    With Application
        .ScreenUpdating = False
        .EnableEvents = False
    End With
    ' Set variable for this work as source workbook
    Set sourceworkbook = ActiveWorkbook
    
    ' loop through master excel and assign DWR column and action column based on
    ' what folder resides
    ' assignColforDWRandAction(this changes col B and C in workbook AND 
    '  NOT NEEDED FOR THIS SAMPLE
    'Search for "Not Matched" in Path or the action Flag = A for Mask Sub
    searchstring = "Not Matched"
    
    iFirstRow = 1
    'Get last Row that has data
    iLastRow = Application.WorksheetFunction.CountA(Range("A:A"))

    'Loop through DWR IFS worksheet to identify the folders and files that need to have DWR cleared
    For index = iFirstRow To iLastRow
    
        'Set ActiveCell
        'Get FileName for current row
        Range("A" & index).Select
        strPathFileName = ActiveCell.Text
        
        'Get DWRcol for current row
        Range("B" & index).Select
        strDWRcol = ActiveCell.Text
        
        If Dir(strPathFileName) <> "" Then
            Range("C" & index).Select
            strActionFlg = ActiveCell.Text
            Range("D" & index).Select
            PassFailFlag = ActiveCell.Text

                          ' Check to make sure the action flag is for delete and this has not been processed before
                If (strActionFlg = "B") And _
                PassFailFlag = "" Then
                    'Get Action Flg to determine how DWR to process
        
                    'Call to sub for files where column will be deleted
                    DeleteDWRColumn strPathFileName, strDWRcol
                    
                    Worksheets(1).Range("D" & index).Activate
                    ActiveCell.Value = "Passed"
                    Worksheets(1).Range("E" & index).Activate
                    ActiveCell.Value = "File Update: " + (strPathFileName) + " - Column " + (strDWRcol)
                End If
        Else
            Worksheets(1).Range("D" & index).Activate
            ActiveCell.Value = "Failed"
            Worksheets(1).Range("E" & index).Activate
            ActiveCell.Value = "There is no file with this name: " + (strPathFileName) + " - Column " + (strDWRcol)
            ' MsgBox "There is no file with this name: " + (strPathFileName), vbInformation
        End If
    Next index
    
    MsgBox "DWR IFS Clean-up complete"
End Sub


Sub DeleteDWRColumn(strPathFile As String, strCol As String)

    Dim fileFormatNumber As Long
    ' These next can be deletecode
    Dim workbooknamebefore As String
    Dim workbooknameafter As String
    Dim srcwb As Workbook
    Dim writewb As Workbook
    Dim SaveFormat As Long

    strCol = strCol + ":" + strCol

    Workbooks.Open strPathFile
    Sheets(1).Select
    'save destination workbook
    Set destworkbook = ActiveWorkbook
    'Deletes entire column
    Range(strCol).Delete
    
    fileFormatNumber = CheckFileFormat()
      If fileFormatNumber <> 56 Then
        SaveFileNewFormat (strPathFile)

    Else
        workbookname = destworkbook.Name
        workbookpath = destworkbook.Path

        With Workbooks(workbookname)
            ' just in case there is a compatibility issue
            ActiveWorkbook.CheckCompatibility = False

            .Save
            .Close
        End With
    End If
    
End Sub

Function CheckFileFormat()

    Dim FileExtStr As String
    Dim FileFormatNum As Long
    Dim Sourcewb As Workbook
    Dim Destwb As Workbook
    Dim TempFilePath As String
    Dim TempFileName As String
    'deletecode
    'With Application
    '    .ScreenUpdating = True
    '    .EnableEvents = True
    'End With

    'Determine the Excel version and file extension/format

        If Val(Application.Version) < 12 Then
            'You use Excel 97-2003
            FileExtStr = ".xls": FileFormatNum = -4143
            MsgBox "Excel Version is < 12 " & Application.Version

        Else
            'You use Excel 2007-2010
            'We exit the sub when your answer is NO in the security dialog that you
            'only see when you copy a sheet from a xlsm file with macro's disabled.
            'If Sourcewb.Name = .Name Then

                If ActiveWorkbook.FileFormat <> 56 Then
                    MsgBox "File Format <> 56, File format is " & ActiveWorkbook.FileFormat
                End If
                
                Select Case ActiveWorkbook.FileFormat
                Case 51: FileExtStr = ".xlsx": FileFormatNum = 51
                Case 52:
                    If ActiveWorkbook.HasVBProject Then
                        FileExtStr = ".xlsm": FileFormatNum = 52
                    Else
                        FileExtStr = ".xlsx": FileFormatNum = 51
                    End If
                Case 56: FileExtStr = ".xls": FileFormatNum = 56
                Case Else: FileExtStr = ".xlsb": FileFormatNum = 50
                End Select
            
        End If
        
    'Return file format to calling sub
    
    CheckFileFormat = FileFormatNum
    'deletecode
    'With Application
    '    .ScreenUpdating = False
    '    .EnableEvents = False
    'End With

    
End Function

Sub SaveFileNewFormat(PathFile As String)

'Working in Excel 97-2007
    Dim FileExtStr As String
    Dim FileFormatNum As Long
    Dim Sourcewb As Workbook
    Dim Destwb As Workbook
    Dim TempFilePath As String
    Dim TempFileName As String
    'deletecode
    'With Application
    '    .ScreenUpdating = False
    '    .EnableEvents = False
    'End With

    Set Sourcewb = ActiveWorkbook
    
    FileExtStr = ActiveWorkbook.Name
    

    'Copy the sheet to a new workbook
    ActiveSheet.Copy
    Set Destwb = ActiveWorkbook
    
    FileExtStr = ActiveWorkbook.Name
    
        FileExtStr = Sourcewb.Name
        FileExtStr = Destwb.Name
    
    'Save the new workbook and close
    
    With Destwb
        .SaveAs PathFile & ".xlsx", FileFormat:=51
        .Close SaveChanges:=False
    End With

    'Close and do not save the original workbook with non 56 file format
    With Sourcewb
        .Close SaveChanges:=False
    End With

    FileExtStr = ActiveWorkbook.Name
    
    Worksheets(1).Range("F" & index).Activate
    ActiveCell.Value = "File Created " + (PathFile) + ".xlsx" + " File Format = 56 "

End Sub