checking whether a number of cells have values

Hi, is there a way to use IF statement to check whether cells have values in them? I'm using this code which doesn't work

If Worksheets("Main").Range("O5:O16, P5:P16").Range <> "" Then
'code here
end if

The alternate i'm thinking of is individually checking each cell

If Worksheets("Main").Range("O5").Range <> "" Then
if worksheets("Main").range("O6").range<> "" then
'code here
end if
end if

but it will make the codes look messy.