What you're referring to is the disabling/enabling of Events.
You can for ex. disable events @ Application level before altering the checkbox value such that the change event is not invoked, subsequently enabling events such that going forward clicking it manually does invoke the handler, eg:
Handler:
Private Sub CheckBox1_Click()
MsgBox "Hello"
End Sub
Other Routine to alter Checkbox but not to invoke Handler
Public Sub Example()
Application.EnableEvents = False
CheckBox1.Value = True
Application.EnableEvents = True
End Sub
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