Conditional Lock Cell

Hello,

I'm new to programming and I have been looking on how to create a simple worksheet for a hotel manager where I can lock two different cells when another cell has entry. (It's pretty much showing that when a two bedroom is reserved, the one bedroom and hotel room beside it cannot be reserved.) I included an attachment. For example, is if B36:F36 (or merged together with entry) has an entry then B15:F15 and B31:F31 become locked and cannot enter in these cells.

Is it possible to add a box that is required to fill out when entering in these rows B35:AE38 so when a those cells are entered (two bedroom is reserved) a pop up window will show up when you select the reflecting hotel rm or one bedroom?

Would there be an easier way to do the conditional lock other than using Macro?