What happens when you switch the setting to enable macros - do they run then?

Yes Ali, you are the reason I "upgraded" to Onedrive.
So, I guess it must be my fault, then?

they should run regardless on Desktop/ cloud.
They would not run if you were trying to run them from the browser interface, but I presume that's not what you are trying to do.

I'll leave it to someone who won't ask 'irrelevant' questions.