is there a better way to do If i2 = 25 Or i2 = 50 Or i2 = 75 Or i2 = 100

By the way, here is an alternate method you could use...

.....
For I2 = 1 To 300
  If I2 / 25 = Int(I2 / 25) Then
    ' I2 is exactly divisible by 25... do what you want here
  End If
Next
.....