Button Issues - moving, resizing and worse

Hey all - this is making me crazy and I cannot find any solutions. Hoping it something relatively straight forward.

I have an Excel 2016 workbook that has 7 active x buttons on one sheet. I have the properties set so they should not move or size with the columns. When the workbook first opens, they are neat and orderly and do what they should do. Then after I run any of the macros that they initiate, the become unusable.
-- If I click button A, while the mouse is depressed it partially overlays Button B and doesn't execute the macro.
-- If I click button B, while the mouse is depressed it appears 6 inches to the right of where the button is on the sheet (I'll try to attach a small MP4)

When I save and reopen the file, the buttons seem to have redrawn - they overlap, the font is different and they don't work consistently (Perhaps related to pixel location of where I'm clicking)

Anybody have any ideas what makes this happen, and how I can put a stop to it? It's making development extremely time consuming!