You put your first set of data in a sheet called Sheet1, and the second set of data in a sheet called Sheet2. Then in Cell A1 in a third sheet (Sheet3)enter this formula:
This gives you the difference of the A1 cells in Sheet1 and Sheet2.
Copy this formula to all the cells needed in Sheet3, to compare the whole Range.
If your sheets is in different Workbooks, you can do the same. Open both Workbooks. Choose a sheet to put your result in. This could be in a new Workbook or in a separate sheet on one of the two workbooks you compare.
Select Cell A1 in your result sheet.
Enter "="
Select cell A1 in the first sheet to compare.
Enter "-"
Select cell A1 in the second sheet to compare
Press "ENTER"
Then you get a formula with the correct refferences.
Copy to all other cells that need a compare result.
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