Microsoft recommends that site collections should not:
Contain more than 250,000 sites (supported), which, for the record, is a mind-blowingly large number;
Contain more than:
100 GB of information (relatively small considering the number of sites it can support) in SharePoint 2013; or
1 TB of information in SharePoint Online (default starts at 1 GB so you have to request an increase from your IT administrator);
Have more than 2 million users (supported), which is, again, a huge number (and probably only important to IT since they likely control who users are);
Have more than 5,000 users in a SharePoint group (supported), which is actually somewhat contradictory to the last item; and
Utilize more than 10,000 SharePoint groups.
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