Calculating Shipment Rates Base on Origin City and Destination City

Hey, what I am trying to figure out is how to match a series of rates for a destination city depending upon the origin city. I have figured out how to match rates from origin city to multiple destination cities but have not figured out how to change the series of rates when the origin city changes. These rates will be calculated on the "calculator" in the excel document depending on the cities chosen.

I have attached a document that shows a simplified version of what I am trying to do.

Any help would be greatly appreciated. Thanks!